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The principal in vivo oxygenase products of arachidonic acid and linoleic acid in psoriatic skin scales are 12-hydroxyeicosatetraenoic acid (R/S ratio = 5.7), 13-hydroxyoctadecadienoic acid (S/R = 1.9), and 9-hydroxyoctadecadienoic acid (R/S = 2.4). Definition of the enzymatic origin of these fatty acid derivatives is an important step in assessing their possible role in the pathogenesis of pso...

OBJECTIVES This is the first investigation of dietary practices amongst multiple early medieval populations (AD 500-1000) from Wales and the Isle of Man using carbon, nitrogen, and sulphur isotope analysis. The analysis will illuminate similarities or differences between the diets and subsistence strategies of populations occupying different geographical regions, specifically those living in ma...

UNLABELLED Objective(s) : The 15-Lipoxygenase-1(15-LOX-1) pathway has become of considerable interest as a promising molecular approach for the modulation of cancer cell growth. 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) is a main metabolite of 15-LOX-1 which is proposed to influence the cancer cell's growth. This study aims to investigate the role of 13(S)-HODE in the regulation of cell gro...

Characterization of the chemical form and stereo-specificity of the fatty acid derivatives of arachidonic and linoleic acid in psoriatic epidermis is needed to define the enzymatic origin of these compounds and their possible role in pathogenesis. In an analysis of psoriatic skin scales, both free and esterified 13-hydroxyoctadecadienoic acids were the principal fatty acid derivatives, present ...

Abbreviations: 12/15-LOX, 12/15-lipoxygenase; 5-LOX, 5-lipoxygenase; 5/12/15(S)HETE , 12/15(S)-hydroxyeicosatetraenoic acid; 13(S)-HODE, 13(S)hydroxyoctadecadienoic acid; LxA4, lipoxin A4; STAg, soluble toxoplasma antigen; ICSBP, Interferon Consensus Sequence Binding Protein; IRF-8, Interferon Regulatory Factor-8, BMNCs, Brain Mononuclear Cells Copyright © 2009, American Society for Microbiolog...

In previous studies, we have found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid, are decreased in human colorectal cancers and that nonsteroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in human colorectal cancer cells. NSAIDs similarly induce apoptosis in esophageal cancer cell...